Global Wolf educates viewers on the history of the human-wolf relationship throughout the world and follows international wolf researchers as they work to preserve a species once hunted to the edge of extinction. Gesa Kluth, a European wolf biologist, plays happily with captive research wolves as she explains they are quite friendly to each other and the humans they recognize. Her quest is to determine if the German wolf is truly extinct or if there may be hope to revitalize the regional lineage.